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Published date: 2025/02/12
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The ΔF508 mutation is a deletion of the C-G pair from position 507 along with the first two T-A pairs from position 508, leaving the DNA sequence A-T-T (paired with T-A-A) at position 507, which is transcribed into the mRNA codon A-U-U. ΔF508 is current on a minimum of one copy of chromosome 7 in approximately one in 30 Caucasians. Presence of the mutation on both copies causes the autosomal recessive disease cystic fibrosis. Scientists have estimated that the unique mutation occurred over 52,000 years ago in Northern Europe although cystic fibrosis patients of other ethnicities are additionally known to harbor the mutation. If you beloved this article so you would like to acquire more info pertaining to spooky2 starter kit generously visit the web-page. The younger allele age may be a consequence of previous selection.
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